PRGF – ENDORET®: closed technique
BTI is considered a worldwide scientific reference in regenerative medicine. This recognition is the result of the successful use of Endoret® (PRGF®) in different medical specialties such as dentistry, traumatology, dermatology, ophthalmology, sports medicine, vascular surgery, aesthetics, among others.
Endoret® PRGF® is a closed system, with the necessary equipment and unitary and disposable kits certified for such use that allows a rapid preparation of plasma under sterile conditions and its immediate application.

Advantages of PRGF®
Autologous and rich in Growth Factors
- Taken from patient’s blood, so there is less possibility of side effects
- It promotes homeostasis
- Stimulates cell proliferation and migration
- It stimulates the endogenous secretion of proteins from the extracellular matrix
Optimal concentration of Growth Factors
- Platelet concentration compared to baseline between 2 and 3 times
- Balance between growth factors:
- Platelet-based (released by platelets)
- Plasma-based (present free in plasma)
Free from leukocytes and inflammatory proteins
- Process includes elimination of leukocytes, Complement C and IgE
- Preserves the integrity of the fibrin matrix over time
Controlled activation
- Promotes the release of growth factors from platelet
- Induces polymerisation of the fibrin matrix
Scientific evidence
- Technology endorsed by more than 200 indexed scientific publications
Endoret® PRGF®: Closed Technique
What is the difference between the closed and the open technique?
- Closed technique:
- Utilizes disposable, single-use kits; the instructions given by the manufacturer of each system must be followed without it being necessary to obtain a certificate of adequacy from the facilities.
- Open technique:
- The method for obtaining PRP should be evaluated and authorised by an inspection by the competent health regulation to verify the suitability of the facilities and the production activities.
